Overview
Spermidine is an exciting compound in many organisms, from animals to plants and even bacteria. It acts as the “superhero” of the cell and is essential to preserving human health. For example, you may have heard that it has anti-aging properties because it activates an autophagic process, which functions as a cellular cleaning mechanism. By eliminating damaged cells and recycling their parts, spermidine extends the life of cells.
But spermidine is more than just a “one-hit wonder.” It also offers protection from diseases such as neurodegenerative, cardiovascular, and cancer. Also, spermidine has anti-inflammatory and antioxidant properties that prevent cell damage. The best part is that many foods we eat, like grains, seeds, and cheese, contain spermidine.
This article discusses the potential of spermidine against age-related conditions through the critical findings in various human and animal studies. In addition, spermidine supplements will be recommended, with Peak Human’s Fasting Pro as one of the best options.
Research Continues in the Potential Benefits of Spermidine in Anti-aging
What is Spermidine?
Understanding Spermidine
Spermidine is a naturally occurring polyamine in all living organisms, including bacteria, plants, and animals. It acts in several cellular processes, including DNA synthesis and repair, cell growth and division, and enzymatic modulation. Recently, studies have raised the possibility that spermidine may have various health benefits, such as cell protection, anti-aging properties, and disease prevention.
In humans, spermidine levels decrease with age, and it has been hypothesized that lowered endogenous spermidine concentrations may be related to age-related deterioration. This theory is supported by current research, which demonstrates that a higher intake of this polyamine with spermidine-rich food reduces overall mortality associated with neurodegenerative, cardiovascular, and cancer diseases.
Spermidine Research
Due to its potential health benefits, spermidine research has recently received significant attention. Studies have been carried out using a variety of model organisms, including mice, worms, flies, yeast, and, most recently, humans.
Initial findings suggest that spermidine’s beneficial actions may all come from its effects on the cell. For example, spermidine increases cells’ lifespan because it has anti-inflammatory and antioxidant properties that protect them from damage. Spermidine can also trigger the body’s natural mechanism for eliminating damaged cells and recycling their parts, known as autophagy, which is critical to aging and age-related diseases.
Where is Spermidine Found?
Animals, plants, and bacteria all have spermidine. Higher organisms have higher amounts of it in their cells, which are essential for cellular functions.
Cellular Metabolism
Spermidine can be found in the cells of every animal organ and tissue, including the brain, heart, liver, and muscles. It can also be found in semen, which supports sperm integrity and protection. The leaves, stems, roots, and seeds are among plants’ tissues containing spermidine. It is also prevalent in cereal grains like oats and wheat.
Dietary Intake
Many foods, such as whole grains, nuts, seeds, and cheese, contain spermidine. Also, it is present in large amounts in fermented foods high in polyamines, like soy sauce, tempeh, and sauerkraut. It is possible to consume spermidine through dietary supplements. Still, it is advisable to seek medical advice before starting any supplement regimen.
What Does Spermidine Do?
Stimulate Cytoprotective Autophagy
Autophagy is a cellular process that involves the breakdown and recycling of defective or abnormal components. It plays a crucial part in preserving cellular homeostasis and is activated in response to various stressors like nutrient deprivation.
ATG8 is a crucial component in the start of autophagy and is activated by spermidine. Spermidine can raise ATG8 levels by preventing the activity of the enzyme spermidine synthase, which breaks down spermidine. As a result, spermidine builds up inside the cell, which starts the autophagic process.
Additionally, it has been discovered that spermidine raises the levels of Beclin-1. This different protein is essential for the onset of autophagy. The autophagosome, a membrane-bound organelle that digests cellular debris and transports it to the lysosome for degradation, is known to interact with the Beclin-1 protein.
Counteract Age-related Pathologies
Age-related diseases can be fought off in several ways by spermidine. Firstly, spermidine can stimulate autophagy, which helps remove harmful or damaged cells from the body. Autophagic activity declines with aging, which helps explain why organelles and macromolecules become more damaged as we age.
Secondly, spermidine is an anti-inflammatory and an antioxidant. Oxidative damage causes organisms to age, which has led to the discovery that inflammation and oxidative stress play a significant role in aging and age-related diseases. Therefore, spermidine delays aging by protecting cells from oxidative stress.
Thirdly, spermidine stimulates the synthesis of collagen, a protein essential for maintaining the strength of skin, bones, and other connective tissues. As we age, our bodies produce less collagen, which can cause wrinkles, age spots, and other aging symptoms. Thus, spermidine aids in the restoration of skin and bone structure and integrity.
What Are Spermidine Benefits?
Through autophagy, spermidine has various positive health effects at the cellular and molecular levels. Spermidine may also be a helpful intervention in reducing age-related diseases, hence increasing lifespan and helping individuals achieve longevity.
Some best-studied spermidine benefits include:
- Promote healthy aging
- Increase lifespan in various organisms
- Promote cell growth and division
- Has anti-cancer properties
- Improve cognitive function
- Enhance nerve cell growth and function
- Reduce inflammation and oxidative stress
- Improve muscle function and strength
- Enhance heart health
- Improve skin health
Studies on Spermidine and Age-related Pathologies
Neurodegenerative Diseases
Research has shown that spermidine may have therapeutic benefits in neurodegenerative illnesses. Spermidine helps prevent the loss of neurons, reduce inflammation, and enhance the performance of mitochondria – the cell’s powerhouses.
Spermidine may also aid in the removal of harmful protein aggregates associated with neurodegenerative illnesses, including Alzheimer’s and Parkinson’s. Yet, more research is necessary to completely comprehend spermidine’s action and possible advantages in managing neurodegenerative disorders.
Concerning Alzheimer’s disease, a study shows that supplementing mice with spermidine might enhance memory and learning capabilities and reduce the formation of amyloid beta plaques in the brain. Yet, this study was conducted on animals. Additional analysis is required to establish whether similar effects will occur in people.
Cardiovascular Diseases
Studies show spermidine may positively benefit cardiovascular health by improving blood flow, lowering blood pressure, and reducing the risk of heart disease.
By lowering the buildup of fat in the blood, spermidine has a preventive impact against heart disease. Also, spermidine enhances the functionality of the endothelial cells that line blood arteries, which is critical for preserving blood flow. As a result, spermidine lowers blood pressure, where the endothelial cells are reinforced. These cells release substances called vasodilators, relaxing the blood arteries and reducing resistance to blood flow.
Spermidine also has an anti-inflammatory impact. High blood pressure and increased resistance to blood flow are both caused by the ability of inflammation to induce blood vessels to constrict. Spermidine could assist in enhancing blood flow and lowering blood pressure by decreasing inflammation.
Cancer and Tumorigenesis
Research shows that spermidine possesses anti-cancer effects, lowering the mortality rate associated with cancer.
It functions by causing cancer cells to undergo cell death (apoptosis) while leaving healthy cells unaffected. Additionally, spermidine stimulates autophagy, a process by which cells break down and recycle their components, eliminating the harmful cells. Spermidine could also help prevent the invasion and growth of cancer cells.
Spermidine treatment causes cancer cells to activate signaling pathways that promote apoptosis. As a result, the DNA of the cancer cell is broken apart, leading to the cell’s eventual death. Spermidine can also block the action of anti-apoptotic proteins, such as Bcl-2, which aids in further promoting cancer cell death. Breast, prostate, colon, and other cancer cells have all been found to exhibit this pathway.
Spermidine Supplementation With Fasting Pro
With 10 mg of spermidine, four times more than any similar supplements, Peak Huma’s Fasting Pro is the ultimate solution to aiding autophagy, boosting the renewing process of cells, preventing age-related diseases, and increasing human longevity.
Fasting Pro has components that simulate fasting and help your body naturally eliminate those old cells. No other product has the incredible potency of Fasting Pro, which is due to the twelve unique autophagy-catalyzing ingredients.
- Spermidine 10 mg
- Pterostilbene 100 mg
- Trans-resveratrol 50 mg
- 3/4 DMC 1 mg
- NMN 100 mg
- Bergamot 250 mg
- EGCG 100 mg
- Alpha-KG 394 mg
- Apigenin 10 mg
- Luteolin 25 mg
- Taxifolin 10 mg
- Trimethylglycine 350 mg
Increasing lifespan and achieving longevity is no longer a secret with Peak Human’s Fasting Pro. Containing potent ingredients that are well-studied for their marvelous effects on human health, the supplement is the best way to add years to your life.
References
- Morselli, E. et al. (2011). Spermidine and Resveratrol Induce Autophagy by Distinct Pathways Converging on the Acetylproteome. Journal of Cell Biology.
- Eisenberg, T. et al. (2016). Cardioprotection and Lifespan Extension by the Natural Polyamine Spermidine.
- Jeong, J. et al. (2017). Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish. Biomolecules & Therapeutics.
- Yang, Y. et al. (2017). Induction of Autophagy by Spermidine is Neuroprotective via Inhibition of Caspase 3-mediated Beclin-1 Cleavage. Cell Death & Disease volume
- Kiechl, S. et al. (2018). Higher Spermidine Intake is Linked to Lower Mortality: a Prospective Population-based Study. The American Journal of Clinical Nutrition.
- Wirth, M. et al. (2019). Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline (SmartAge)-Study Protocol for a Randomized Controlled Trial. Alzheimer’s Research & Therapy.
- Pietrocola, F. et al. (2019). Spermidine Reduces Cancer-related Mortality in Humans.
- Madeo, F. et al. (2019). Spermidine: a Physiological Autophagy Inducer Acting as an Anti-aging Vitamin in Humans.
- Camprecios, G. et al. (2021). Spermidine Supplementation Protects the Liver Endothelium from Liver Damage in Mice.
- Kim, D. et al. (2021). Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca2+ Overload in Retinal Pigment Epithelial Cells Independently of ROS. International Journal of Molecular Sciences.
- Kim, G. et al.(2021). Spermidine-induced Recovery of Human Dermal Structure and Barrier Function by Skin Microbiome. Communications Biology.
- Freitag, K. et al. (2022). Spermidine Reduces Neuroinflammation and Soluble Amyloid Beta in an Alzheimer’s Disease Mouse Model. Journal of Neuroinflammation.
If you have questions about spermidine anti-aging or any health problems discussed here, connect with us and learn more.
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