Longevity, Reproductivity, and Ovarian Aging: What Research Reveals

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Is there a secret to extending our lifespan and slowing the aging process?

While we often associate longevity with a healthy lifestyle, emerging research points to a fascinating connection between the ovaries and how we age.

This article delves into the intricate relationship between ovarian aging and longevity, shedding light on the quest for a longer, healthier life for women.


Understanding the Link Between Ovarian Aging and Longevity

Why Are the Ovaries So Important?

The ovaries are two small, almond-shaped organs in the female reproductive system, but their significance extends beyond reproduction. They play a pivotal role in the complex interplay of the female body, impacting fertility and overall health.


The Natural Materials of Life

The ovaries are the primary source of oocytes (eggs). The production of eggs begins in a female’s fetal stage and then diminishes over time (1-2 million at birth, 300,000-500,000 during puberty, and 1,000-2,000 at menopause). These eggs are essential for conceiving and giving birth, making the ovaries central to the continuation of the human species.


Potent Endocrine Glands

They secrete the hormones estrogen and progesterone, which profoundly affect the female body. During puberty, these hormones initiate and orchestrate various changes, such as breast development and the growth of secondary sexual characteristics. Beyond that, they are vital in regulating the menstrual cycle and supporting a pregnancy.


A Biological Clockwork

Ovulation, when an egg is released from the ovaries, further highlights their importance. This process occurs around the middle of a menstrual cycle, approximately on day 14 of a 28-day cycle. Ovulation allows for fertilization and conception, making the ovaries the biological clockwork that enables the reproductive system to function efficiently.


How Does Aging Affect the Ovaries?


A Natural Part of Aging

Ovarian aging, a natural biological process, brings about significant changes in the ovaries, affecting female fertility and overall health. This process is characterized by the gradual decline in the quantity and quality of oocytes, the female’s eggs.

Ovarian aging is, in part, determined by the number of primordial follicles (PMFs) present at birth. These PMFs represent the pool of eggs that a woman has throughout her lifetime.

Every month, the ovaries release a limited number of eggs, and over time, this pool gradually depletes. This depletion is one of the natural drivers of ovarian aging, leading to reduced fertility as a woman grows older.


The Ovaries Age Faster Than the Rest of the Body

What makes ovarian aging intriguing is that it does not follow the same timeline as the aging of somatic cells, which are all other cells in the body other than sperm and egg.

Research in Human Reproduction Open has shown that ovarian aging occurs at a younger age than somatic cells show signs of aging. These signs may become apparent as early as a woman’s mid-30s, even when other body cells remain relatively youthful.

This finding has led scientists to propose that the ovaries might undergo a distinct aging mechanism or experience accelerated aging, affecting ovarian cells more profoundly.


What Causes Early Ovarian Aging in Some Women?

According to research in the Journal of Reproduction & Infertility (JRI), early ovarian aging, sometimes observed in women in their early 30s, represents biological variations in the natural aging process of the ovaries.

While genetic factors play a significant role in a woman’s ovarian aging trajectory, there are also modifiable factors that can contribute to early ovarian aging. These changes in the ovaries often result in complications, most notably impaired female fertility.


Genetic Predisposition

Some women may inherit a lower ovarian reserve, which means they have a reduced number of primordial follicles at birth. This defect can lead to a more rapid depletion of eggs, ultimately affecting fertility. Early ovarian aging is often linked to two clinical conditions:

  • Premature ovarian failure (POF)
  • Early menopause


Premature ovarian failure (POF) is an ovarian defect characterized by the absence of the first menstrual cycle or depleted ovarian follicles before age 40. This condition results from an accelerated loss of ovarian function and can impact a woman’s fertility.

Early menopause, another consequence of early ovarian aging, occurs when a woman’s ovaries stop producing normal levels of hormones, particularly estrogen. This natural event is sometimes called primary ovarian insufficiency (POI).


Modifiable Factors

Lifestyle choices such as smoking, exposure to environmental toxins, and ovarian surgeries can expedite ovarian aging. These factors can damage the primordial follicles and reduce their numbers, accelerating the depletion of eggs.


How Does Ovarian Aging Affect Female Fertility?


Female fertility decreases with age and is influenced by ovarian aging. The menopausal transition, which leads to the cessation of menstrual cycles and the end of egg production, occurs when the quantity of oocytes falls below a critical threshold. As a result, infertility becomes more likely as women approach their late 30s and early 40s.


Increased Risk of Miscarriage

Research has shown that postponing childbearing can be a “gamble,” as ovarian aging poses challenges for women seeking to conceive. One of the worst complications is miscarriage. As the quality of oocytes declines, chromosomal abnormalities in embryos become more pronounced, leading to higher rates of miscarriage.


Assisted Reproductive Interventions

Ovarian aging also makes it difficult to achieve pregnancy without medical assistance. The declining quantity and quality of eggs can result in prolonged periods of trying to conceive without success, ultimately requiring assisted reproductive interventions.


Increased Risk of Congenital Disabilities

Ovarian aging and advanced maternal age are also associated with an increased risk of complications during labor and delivery, a need for assisted birth or cesarean sections, and a slightly higher risk of specific congenital disabilities.



Research done by the Department of Obstetrics and Gynaecology, Monash University, Australia, has shown that the average age of women at their first childbirth increased from 28.1 years in 2005 to 28.9 years in 2015. Additionally, births to mothers over 35 accounted for 22%, indicating a growing trend of delayed childbearing.

Although these statistics are not significant, such a shift in maternal age has contributed to increased demand for reproductive assistance, which comes with emotional, physical, and financial costs. Still, there are no guarantees of success, as the success rates of assisted reproductive technologies tend to decrease with age.


Ovarian Aging and Longevity: What is the Connection?


The same study published in Human Reproduction Open has shed light on the intriguing connection between ovarian aging and longevity, revealing the complex interplay of pro-longevity and anti-longevity genes within the ovaries.


Materials and Methods

This study examined a dataset of gene expression profiles of germinal vesicle (GV) oocytes from 38 women aged between 25 and 43, which were donated following intracytoplasmic sperm injection (ICSI) treatment according to protocols in the Amsterdam UMC (NL).

Researchers correlated female calendar age and biological age (factors associated with ovarian aging) with gene expression signatures of longevity pathways. To do this, they accessed a repository of age-related genes from the GeneAge database. This analysis led to the identification of 116 genes relevant to longevity, of which:

  • 72 were categorized as pro-longevity genes (associated with extending lifespan when overexpressed)
  • 39 were categorized as anti-longevity genes (associated with extending lifespan when knocked out)
  • 5 had no longevity phenotype



What emerged from this investigation was a fascinating observation: as women age, pro-longevity and anti-longevity genes within the ovaries display distinct trends in gene expression. Anti-longevity genes tended to increase in abundance with ovarian aging, while pro-longevity genes appeared to decrease with age.

This finding suggests that ovarian aging and longevity may be interrelated processes influenced by these opposing gene categories.

The study also revealed a decline in the expression of genes related to DNA damage repair and cell cycle checkpoint regulation with increasing female age. Significantly, these genes are all pro-longevity genes.

This downregulation of pro-longevity genes involved in DNA damage repair and cell cycle checkpoint regulation may contribute to the gradual decline in the quality and quantity of oocytes, characteristic of ovarian aging.


How Can You Delay Ovarian Aging?


Stem Cell and Gene Therapy

Stem cell and gene therapy represents a cutting-edge approach to delay ovarian aging. This intervention involves harnessing the power of stem cells, which are undifferentiated cells with the potential to become various cell types, and genetic modification to preserve ovarian function and slow down the aging process.

Stem cell and gene therapy may involve introducing stem cells into the ovaries to rejuvenate or replace damaged ovarian cells. Additionally, genetic modification techniques can correct or enhance the functioning of genes associated with ovarian aging.

These therapies aim to promote the growth and maintenance of healthy oocytes, thereby extending the reproductive lifespan.


Ovarian Cryopreservation

Ovarian cryopreservation is a fertility preservation technique that involves freezing and storing a woman’s ovarian tissue for future use.

A surgical procedure removes a portion of the ovaries, which contains primordial follicles. This ovarian tissue is then cryopreserved and stored at very low temperatures. When a woman is ready to conceive or preserve her fertility, the tissue can be thawed and re-implanted, potentially restoring her ovarian function.

By freezing ovarian tissue at a younger age, a woman can effectively “pause” her ovarian aging, preserving the quality and quantity of oocytes. This procedure may allow her to conceive later in life when her natural ovarian reserve is typically diminished.


Lifestyle Interventions

Lifestyle interventions are non-invasive and easily accessible strategies to help delay ovarian aging by promoting overall health and well-being.

Lifestyle interventions encompass various measures such as maintaining a healthy diet, engaging in regular exercise, reducing stress, and avoiding harmful habits like smoking and excessive alcohol consumption. These practices can support ovarian health by reducing oxidative stress, inflammation, and other factors that accelerate aging.

Lifestyle choices that promote well-being not only contribute to healthier ovaries but also reduce the risk of chronic diseases, thereby extending a woman’s reproductive lifespan.


How Do You Know if Your Ovaries Are Healthy?


Women with healthy ovaries usually have these characteristics:

  • Regular menstrual cycles, typically between 21-35 days
  • Predictable ovulation around the middle of a menstrual cycle
  • Balanced hormone levels, including estrogen and progesterone
  • A well-functioning pituitary gland regulating hormone production
  • Absence of severe menstrual pain or irregular bleeding
  • No noticeable symptoms of polycystic ovary syndrome (PCOS), such as hirsutism (excessive hair growth) or acne
  • No history of ovarian cysts or tumors
  • Satisfactory ovarian reserve with sufficient eggs


However, the presence or absence of these characteristics can vary among individuals and are often age-dependent. If you want to assess your ovarian health accurately, blood tests can measure specific hormone levels. Chromosome analysis through blood tests can also help identify genetic abnormalities that might affect ovarian function.

Finally, a pelvic ultrasound can provide visual confirmation of ovarian size and the presence of multiple follicles, helping to diagnose certain conditions like polycystic ovaries.


Can You Rejuvenate Your Ovaries Naturally?

Rejuvenating ovaries naturally involves various lifestyle changes and specific supplements to support ovarian health. Here are some essential nutrients and supplements that can help restore the quality and quantity of eggs:

  • Coenzyme Q10 (CoQ10): CoQ10 is an antioxidant that supports mitochondrial function. It provides the energy required for DNA replication, crucial for increasing high-quality egg production.
  • Fish Oil (Omega-3s): Omega-3 fatty acids found in fish oil are beneficial for preserving fertility and enhancing egg quality. They can reduce inflammation and support ovarian function.
  • Vitamin A: Vitamin A plays a role in promoting oocyte quality and enhancing embryo development, making it an essential nutrient for ovarian health.
  • Vitamin E: Vitamin E is an antioxidant that lowers oxidative stress and supports follicular blood supply, a critical factor for high-quality egg development.
  • Zinc: Zinc is essential for promoting high-quality oocyte development, ensuring the genetic material within the egg is in optimal condition.
  • Folate: A folate supplement can boost oocyte quality, maturation, fertilization, and implantation, making it a valuable addition to your fertility support regimen.


*Consult with a healthcare professional before starting any supplement regimen to ensure it aligns with your health needs and goals.


Bottom Line

The connection between ovarian aging and longevity sheds light on the intricate relationship between the female reproductive system and overall life span. Ovarian aging, marked by declining egg quality and quantity, can influence a woman’s overall health and ability to conceive as she advances to later stages of life.

This aging process is intimately linked to the aging of the entire body, making it a crucial factor in a woman’s longevity. Understanding the genetic and molecular mechanisms underlying this connection is essential as it holds the potential to not only delay ovarian aging but also extend a woman’s overall health and lifespan.



Subrat P. et al. (2013). The Concepts and Consequences of Early Ovarian Ageing: A Caveat to Women’s Health. Journal of Reproduction & Infertility.

Vollenhoven B. et al. (2018). Ovarian Aging and the Impact on Female Fertility.

Smits M. et al. (2021). Longevity Pathways Are Associated With Human Ovarian Aging. Human Reproduction Open.


If you have questions about ovarian aging and longevity or any health problems discussed here, contact us and learn more. 

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