In this episode, Dr. Sanjeev Goel and Dr. Varun Dwaraka, Head of Bioinformatics at TruDiagnostic, discuss biologic age testing, focusing on DNA methylation and epigenetics.
They explore how epigenetic changes occur with aging, affecting gene expression. The conversation touches on the history of epigenetic clocks, aiming to predict biological age beyond chronological age. They introduce the DunedinPACE Clock, which shows promise in improving accuracy. TruDiagnostic’s OM Clock integrates various data layers, providing a comprehensive aging assessment. It predicts health outcomes with higher sensitivity and specificity than existing clocks and undergoes ongoing research for response to interventions. For more details, visit www.trudiagnostic.com or connect with Dr. Varun Dwaraka on LinkedIn or Instagram.
Varun Dwaraka PhD is the Head of Bioinformatics at TruDiagnostic, and an aging and longevity investigator specializing in epigenetics and bioinformatics. He has co-authored numerous publications relating to genetics, epigenetic clocks, DNA methylation, and tissue regeneration. In 2020, Dr. Dwaraka was elected as a full member to the Sigma Xi, The Scientific Research Honor Society, and currently serves as a 2023 Foresight Fellow in Biotechnology and Health Expansion, awarded by the Foresight Institute. He also serves on the Scientific Advisory Board for SRW Labs based in New Zealand, offering insight into the application and interpretation of epigenetic age biomarkers. Dr. Dwaraka is passionate about implementing machine learning methods to advance predictive medicine, identify novel biomarkers, and create algorithms to better understand the biology of aging.
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