We may think of aging as an inevitable natural process everyone experiences, but what if we could delay it through eating certain foods or supplements. Fisetin is such a potent antioxidant that research has shown may slow aging in animals.
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5 Fisetin Benefits: a Key to Longevity
Researchers have been looking into fisetin’s benefits and its potential for treating various diseases. Research has revealed five benefits of fisetin.
What Is Fisetin?
Fisetin is a flavonoid found in strawberries, apples, persimmons, grapes, and other fruits and vegetables. Fisetin gives fruits and vegetables their vibrant colors in addition to the health benefits it brings.
A study in Japan found that strawberries (160 μg/g), apples (26.9 μg/g), and persimmons (10.5 μg/g) have the highest concentration of fisetin. Other fruits and vegetables that are rich in fisetin are lotus roots (5.8 μg/g), onions (4.8 μg/g), grapes (3.9 μg/g), and kiwi (2.0 μg/g).
Senescent cells are involved in the progression of aging and age-related illnesses. These cells naturally build up in various organs as the human body gets older. In other words, aging and sickness occur when there is an accumulation of senescent cells.
Fisetin has potent senolytic properties that help remove senescent cells and enhance human health through heightened cell regeneration. It appears that fisetin’s senolytic properties can help slow down the aging process and improve lifespan.
A study showed that fisetin reduces senescence, a process in which old cells stop dividing and permanently withdraw from the cell cycle. Furthermore, the administration of fisetin to older mice reduced age-related pathology and extended median and maximum lifespan.
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Several studies have shown that fisetin plays a role in preventing some cancers, including lung cancer, colon cancer, and prostate cancer.
An initial study investigating the effect of fisetin on lung cancer showed that fisetin could prevent adhesion, migration, and invasion of human A549 lung cancer cells. Another study showed that the viability and clonogenicity of A549 lung cancer cells were both reduced by fisetin.
Colon cancer (sometimes called colorectal cancer) is one of the leading causes of cancer-related mortality in our society. Fisetin targets numerous pathways in colon cancer cells to suppress growth and induce the process of programmed cell death (apoptosis).
In a 7-week study consisting of 37 colon cancer patients undergoing cancer treatment, a daily dose of 100 mg of fisetin reduced inflammation, (linked to colon cancer growth and spread)), and heightened treatment responsiveness.
Fisetin has proven to be a potent inhibitor of prostate cancer cell growth. Fisetin also functions as a PI3K/AKT and mTOR signaling dual inhibitor. According to a recent study, fisetin treatment results in autophagic-programmed cell death. This study suggests that fisetin could be a helpful chemotherapeutic agent in treating prostate cancer.
Improves Cognition and Memory
Many clinical conditions are linked to impaired cognition and memory, including neurodegenerative diseases and head trauma, stroke, and a range of drug-related toxicities. As people become older, their cognitive abilities sometimes deteriorate.
Fisetin has several biological properties that might help treat neurodegenerative diseases. It reduces progressive neuronal loss by protecting nerve cells from oxidative stress-induced death and by promoting nerve cell differentiation.
Fisetin, when orally administered, also improves object recognition memory in mice in a behavioral experiment, suggesting that fisetin might be a potential compound for treating cognitive and memory impairment.
Reduces Depression and Anxiety
Depression is a widespread condition that affects an estimated 3.8% of the world’s population. According to the World Health Organization (WHO) report, 280 million people worldwide suffer from depression.
A study aiming to determine the antidepressant potential of fisetin and its mechanism showed that fisetin alleviates depression and anxiety in mice by boosting serotonin and norepinephrine. Serotonin and norepinephrine are the neurotransmitters that play crucial roles in mood disorders.
Boosts Heart Health
Fisetin has been proven in several animal studies to help boost heart health by reducing cholesterol and protecting myocardial cells.
In a study aiming to test whether fisetin could regulate cholesterol homeostasis, fisetin supplementation reduced the cholesterol levels in rats with diet-induced high cholesterol. Fisetin has also been proven to protect against diet-induced obesity in another study. According to the findings, fisetin prevents obesity in mice fed a high-fat diet.
Another study on the effects of fisetin against myocardial ischemia found that fisetin therapy preserved myocardial fiber and lowered the proportion of dead myocardial cells.
Understanding these five fisetin benefits can help you improve your life quality, prevent some age-related diseases, and help you achieve longevity.
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